Primary hyperoxaluria (PH) is a rare genetic disorder characterized by the overproduction of oxalate, a substance that is normally excreted in urine. This condition results from a defect in one of the enzymes involved in glyoxylate metabolism in the liver. Oxalate combines with calcium in the kidneys, leading to the formation of calcium oxalate stones and crystal deposits, which can cause kidney damage and, in severe cases, systemic oxalosis (oxalate accumulation in other tissues).
Types Of Primary Hyperoxaluria
- PH Type 1 (PH1): Caused by mutations in the AGXT gene, leading to a deficiency in alanine-glyoxylate aminotransferase (AGT). This is the most common and severe type.
- PH Type 2 (PH2): Caused by mutations in the GRHPR gene, leading to a deficiency in glyoxylate reductase-hydroxy pyruvate reductase.
- PH Type 3 (PH3): Caused by mutations in the HOGA1 gene, leading to a deficiency in 4-hydroxy-2-oxoglutarate aldolase.
Symptoms Of Primary Hyperoxaluria
1)Recurrent Kidney Stones:
Painful episodes of kidney stone formation, often start in childhood or adolescence.
- Hematuria:
Blood in the urine, visible or microscopic.
- Urinary Tract Infections (UTIs):
Frequent UTIs due to blockages caused by kidney stones.
Renal Colic
Severe pain in the back or side due to stones moving through the urinary tract.
Progressive Kidney Damage:
- Chronic Kidney Disease (CKD):
Gradual loss of kidney function due to oxalate buildup.
- End-Stage Renal Disease (ESRD):
Complete kidney failure requiring dialysis or transplantation.
Causes Of Primary Hyperoxaluria
- Gene Involved: Mutations in the AGXT gene:
The AGXT gene encodes the enzyme alanine-glyoxylate aminotransferase (AGT), which is normally found in the liver’s peroxisomes. Mutations lead to either an absence or dysfunction of AGT, causing glyoxylate to convert into oxalate instead of being detoxified.
- Primary Hyperoxaluria Type 2 (PH2):
Gene Involved: Mutations in the GRHPR gene.
Mechanism: The GRHPR gene encodes the enzyme glyoxylate reductase/hydroxypyruvate reductase (GR/HPR). Dysfunction in this enzyme leads to an inability to metabolize glyoxylate, resulting in excessive oxalate production.
- Primary Hyperoxaluria Type 3 (PH3):
Gene Involved: Mutations in the HOGA1 gene.
: The HOGA1 gene encodes the enzyme 4-hydroxy-2-oxoglutarate aldolase (HOGA). Mutations disrupt the metabolism of hydroxyproline, leading to glyoxylate accumulation and subsequent oxalate overproduction.
Homeopathic Treatment Of Primary Hyperoxaluria
Homeopathy individualized treatment based on the person’s physical and emotional state. While there is no specific “cure” for primary hyperoxaluria in homeopathy, some remedies may help manage symptoms or reduce the risk of stone formation. Commonly suggested remedies include:
- Berberis vulgaris: Often used for kidney stones with sharp pain radiating to the groin or bladder, especially if there’s burning during urination.
- Lycopodium clavatum: Beneficial for right-sided kidney pain, frequent urination, and difficulty passing stones.
- Cantharis: Used when there is intense burning and pain during urination.
- Sarsaparilla: Recommended for severe pain at the end of urination or when stones are present.
- Calcarea carbonica: Suitable for individuals prone to stone formation, especially if they have a family history of kidney issues.
- Hydrangea: Known as a “stonebreaker,” it may help dissolve small stones and ease their passage.
FAQs Of Primary Hyperoxaluria
1)How is Primary Hyperoxaluria diagnosed?
Diagnosis involves:
Genetic testing to identify mutations
Urine tests to measure oxalate levels
Liver biopsy in some cases to confirm enzyme deficiencies
2)How is Primary Hyperoxaluria treated?
Dietary modifications: Low oxalate and high fluid intake
Medications: Vitamin B6 (for PH1), inhibitors of oxalate production
Dialysis: For kidney failure or oxalate buildup
Liver or kidney transplantation: In severe cases, a liver transplant may correct the enzyme deficiency.
3)Can Primary Hyperoxaluria be cured?
A liver transplant can cure the enzyme deficiency but is typically reserved for severe cases. Ongoing treatments aim to manage symptoms and slow disease progression.
4)Can Primary Hyperoxaluria affect children?
Yes, PH often presents in childhood, but symptoms can appear at any age.
5)How can complications be prevented?
Early diagnosis, regular monitoring, hydration, and adherence to medical advice can help prevent kidney damage and other complications.
Let me know if you’d like more detailed information on any aspect!
To schedule an appointment or learn more about our treatment, please visit our website or give us a call +91 9595211594 Our friendly staff will be happy to assist you. If you’re searching for the best homeopathy doctor, we are here to help.
Follow us on Facebook, Twitter, and Instagram for valuable insights into the world of homeopathy and holistic health.
Facebook – https://www.facebook.com/homeocareclinicpune
Instagram – https://www.instagram.com/homeocareclinic_in
Website – https://www.homeocareclinic.in
Chat with the best homeopathic doctor privately
If you have any queries regarding your disease or any symptoms, Click to send a WhatsApp message. Our best homeopathy doctor will be happy to answer you.
Book an Appointment
If you want to visit our clinic, Click to book an appointment.
Online treatment
If you are a busy professional, or you are living in a remote town or city, with no best homeopathic doctor near you, Clickhere to start an online homeopathic treatment with the world’s exclusive, most experienced, and best homeopathic clinic, managed by Dr. Vaseem Choudhary world-renowned homeopathic doctor expert.